Health & Beauty - September 2011
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WANT BETTER HAIR? KNOW YOUR HAIR!


By: Mary Campbell
Posted: 08/27/11

All of my clients say that they love their hair when they leave the salon and that they can never make it look that good at home. I tell them that there are three reasons for this.
    1. Styling Products
    2. Styling Tools
    3. Time
Two of them I can help with and one is up to them.

If you have the right products for your hair type and are using prep, styling, and finishing products, you will achieve the style you are looking for. Prep products are usually creams or serums that will resist humidity to hold the style and protect from the heat of your styling tools. Styling products are the ones you put in to achieve your desired look, whether it be a mousse for volume or a serum for straightening. Finishing products do exactly that, they finish the style and are usually hair sprays or texturizing products.

Styling tools are key. If you are using a dinosaur blow dryer, chances are it doing more damage to your hair than you think it is. Blow dryers as they age can produce more heat than is healthy for your hair. Blow dryers that produce ions are safer for the hair and will add shine and reduce drying time.

If you use a round brush to style your hair, it should be ceramic or at least ceramic coated. If it is just metal, it can burn your hair during styling. Also, if it is ceramic or coated, check regularly for chips as these can pull your hair causing breakage and split ends. Flat irons should only be ceramic plates, this ensures even heating and requires less passes on the hair to fully straighten. Irons should be checked for chips as well to prevent breakage and spilt ends.

The last factor in achieving you ultimate style is time. I know hairdressers make it look so easy and it only took 20 minutes! However, being that we do this all day long, we are very adept at it. Practice makes perfect. Also, we get to work with our arms in front of us and the regular person has to be a yoga master to hold the blow dryer and brush. So don't get discouraged, but leave yourself plenty of time to style your hair and you will love the end result!

Questions, Comments, Concerns?
mary.townbiz101@hotmail.com
www.tangerenz.com
(805) 648-5564

NAIL PSORIASIS



By: Mary Campbell
Posted: 08/27/11

While researching a past article on the skin condition psoriasis, I found that it also contributes to fingernail and toenail disorders. Of the approximately 7 million Americans that have psoriasis, 10-55% are also affected by psoriatic nail disease. Out of the diagnosed cases of psoriasis with arthritis, 53-86% of those people have psoriatic nail disease. Only 5% of people with nail psoriasis do not have psoriasis of the skin. Psoriasis is a genetic skin disorder; however, why it affects the nails in some cases is unknown, but is commonly thought that genetics, immune system, and environment are all factors.

If psoriasis is affecting your nails you may have some of the following symptoms:
  • Discoloration under the nail plate resembling oil or blood, usually a light yellow/red color,
  • Pitting of the nail,
  • Lines forming the width rather than the length of the nail,
  • White patches across the nail plate,
  • Subungual huperkeratosis or thickening of the skin under the nail,
  • Loosening of the nail,
  • Crumbling of the nail,
  • Dilated tortuous capillaries in the dermal papillae, when the capillaries in the fingertip bleeds between the nail and the skin, and/or
  • Redness of the lunula (moon shape at the base of the nail).
If you have any of these symptoms and also suffer from psoriasis of the skin, see your doctor. There he/she can determine if your condition is in fact psoriatic nail disease. Along with psoriasis of the skin, there is no cure, only treatment options for psoriatic nail disease.

Treatments start at home with proper nail care. Trimming any loose nail to where it meets the skin is recommended. However, be gentle as to not cause further injury or risk of infection. The nail can also be chemically or surgically removed if the doctor feels that will be the best way to re-grow healthier looking nails. Your doctor may also prescribe topical creams or suggest a steroid injection. Phototherapy treatments are commonly used as well the use of systemic therapies (internal drugs). Prevention is the key to this socially debilitating disorder. However, if you do suffer from this issue, you can contact the National Psoriasis Foundation for support.

Questions, Comments, Concerns?
mary.townbiz101@hotmail.com
www.tangerenz.com
(805) 648-5564

ITCHY SITUATION


By: Mary Campbell
Posted: 08/27/11

Approximately 2-3% of the American population suffers from a chronic skin condition called psoriasis. It is a genetic condition caused by skin cells that produce themselves up to 10 times faster than normal skin cells.

Its symptoms include plaques of red skin covered by white scaly patches and most likely affect the knees, elbows, scalp, torso, hands and feet. It can also be related to disorders of the fingernails and toenails, as well as it can be associated with arthritis. There is no cure, only treatments available for this skin disorder.

As one of the small percentage of people who suffer from psoriasis, I know how difficult and awkward this disorder can be. From the near constant itching and tell tale red patches on my elbows and knees, I have tried nearly everything possible. Also, being that its symptoms are triggered by factors ranging from infections, allergens, emotional trauma, and stress keeping psoriasis in check is a never-ending battle.

The constant itchiness from psoriasis often causes stress to both the non-stressful (easy going) and stress-based personality, thereby, increasing the psoriasis symptoms resulting in a vicious circle. It's kind of like, "what came first the chicken or the egg?" Regardless of what anyone else might say, psoriasis is a physical disease not mental.

There are several treatment approaches for psoriasis, starting from topical treatments to internal medicine. Topical treatments can vary from over the counter creams to steroid based creams/ointments prescribed by a doctor or dermatologist. There are also phototherapy treatments. As psoriasis symptoms relax with sun exposure, focused treatments of UVB and UVA rays will often reduce the severity of flare-ups. Systemic treatments can help for psoriasis that is more severe and non-responsive to topical treatments. These treatments, however, have other side effects that need to be monitored by a doctor. There are also the newest treatments available through biologic drugs. They have fewer side effects than systemic treatments, and prove promising to treat psoriatic arthritis as well.

I have tried every over the counter topical cream I could find. I've tried straight petroleum, acne creams (the salicylic acid helps remove the dead skin flakes), emu oil, and various plant oils. They all help with a symptom of sorts, but none really remove the issue. I have also tried several different steroid based creams from a dermatologist. They worked great and I was symptom free for quite a while, but I found if you miss one day, the flare-ups are worse than the condition was to start. Also, you can buildup a tolerance to the cream (which is why I had to try several). I have not tried any of the internal treatments. My psoriasis is considered mild and the internal treatments are for moderate to severe symptoms.

I guess I should be considered lucky that my psoriasis is mild. It only affects my elbows and knees with the occasional hot spot flaring up somewhere else. I have met those less fortunate with its red scaly patches all over their hands, arms, faces, and scalps. So, I'll rub in my latest cream and hope for the best. All in all, psoriasis is a frustrating issue that is slowly making its way closer to a better treatment solution. For more support, contact the National Psoriasis Foundation.

Questions, Comments, Concerns?
mary.townbiz101@hotmail.com
www.tangerenz.com
(805) 648-5564

CANCER BREAKTHROUGH OF DRUGS
THAT ARE TARGETING SPECIFIC GENES

Posted: 07/30/11

On June 6, 2011, CBS News correspondent Dr. Jon LaPook reported a cancer breakthrough of drugs that are targeting specific genes.

"It's big news in the fight against cancer: Two new studies report dramatic progress in treating advanced melanoma and lung cancer. Both of these treatments use an approach that is creating a lot of excitement among doctors -- tailoring drugs to the genetic makeup of individual patients, and the results can be remarkable."

According to Wikipedia, Crizotinib (also known as PF-02341066 or 1066), is an ALK (anaplastic lymphoma kinase) inhibitor of the aminopyridine chemical series that is being developed by Pfizer Incorporated. It is currently undergoing clinical trials testing its safety and efficacy in treating several forms of cancer, particularly non-small cell lung carcinoma (NSCLC), anaplastic large cell lymphoma, neuroblastoma, and other advanced solid tumors in both adults and children.

Crizotinib Mechanism Of Action

Crizotinib is an anaplastic lymphoma kinase (ALK) inhibitor under study in patients with advanced NSCLC carrying the echinoderm microtubule-associated protein-like 4 anaplastic lymphoma kinase (EML4-ALK) fusion gene. The protein product of this fusion has constitutive kinase activity that is carcinogenic. Crizotinib competes with ATP for the ALK kinase domain of this fusion protein. About 5% of patients with lung cancer or NSCLC carry the EML4-ALK fusion. Patients with this gene inversion are typically non-smokers who do not have mutations in the epidermal growth factor receptor gene (EGFR) or in the KRAS gene.

Approximately 4% of the 220,000 Americans diagnosed with lung cancer each year have the ALK fusion gene, and 45,000 newly diagnosed NSCLC patients are ALK positive worldwide.

ALK gene mutations are also thought to be important in driving the malignant phenotype in a significant percentage (15%) of cases of neuroblastoma, a rare form of nervous system cancer that occurs almost exclusively in very young children.

Other studies suggest that Crizotinib may also act via inhibition of angiogenesis in malignant tumors. Crizotinib appears to still be in the clinical trials stages on patients who qualify for the trial of advanced disseminated anaplastic large-cell lymphoma, and neuroblastoma.



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